Basic Information
VIS ID
TVIS44019624
Fusion event
HTLV-1-MCTP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
94168155/94832450 (Hg38)
End
94168155/94832450 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5B
Target gene
MCTP1
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-4446-5p ; hsa-mir-510-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-6505-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-642a-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6832-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-203a-3p
Nearest miRNA
hsa-mir-10397/Upstream/1211662; hsa-mir-103a-1/Downstream/1246688;
Nearest TSS
ENST00000502646/Upstream/43661; ENST00000503710/Downstream/97251;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/213312, chr5-CpG: 161/Downstream/451305
Upstream sequence
AAAGAAAGTTCCCAGGTAATCACCGCACCTTCCCCAAGAAGACCCAAGCTTTCAAAGCTTCATTTCTACCTAAGGTTATTTTTGCTGGGAAAATATGTCT
Downstream sequence
GTGATTTCTTTGATCGACGATGTGAACATTTATATCTCCCTCTATAAATTGTTTTGAAAACATGTATTTGGCTTCTTTGACTCATGGTTTCCAGCTTATC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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