Basic Information
VIS ID
TVIS44019637
Fusion event
HTLV-1-QRSL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
107113948/106666073 (Hg38)
End
107113948/106666073 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA6F
Target gene
QRSL1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-769-5p ; hsa-mir-200b-3p ; hsa-mir-3127-5p ; hsa-mir-6754-5p ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-211-3p ; hsa-mir-759 ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-892c-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6760-5p ; hsa-mir-10a-3p ; hsa-mir-4284 ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-7113-5p ; hsa-mir-6823-5p ; hsa-mir-6890-3p ; hsa-mir-1306-5p
Nearest miRNA
hsa-mir-10398/Upstream/7541377; hsa-mir-1202/Downstream/118052;
Nearest TSS
ENST00000381078/Upstream/36459; ENST00000424162/Downstream/29462;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/152963, chr6-CpG: 236/Downstream/307267
Upstream sequence
AGTTAGCCTCTGTCTCTCTAAAACAGTAAACATATCTTACAAATTAAAATGACTTTTAggctgggtgcagtggctcacacctgtaatcccagcactttgg
Downstream sequence
gaggccaaggcgagcggatcatgaggtcagaagatctagaacagcctggtcaacatggtgaaaccccgtctctactaaaaatacaaaaattagccaggct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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