Basic Information
VIS ID
TVIS44019639
Fusion event
HTLV-1-AFG1L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
108620778/108299574 (Hg38)
End
108620778/108299574 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6F
Target gene
AFG1L
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-1228-5p ; hsa-mir-6770-3p ; hsa-mir-4730 ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-4467 ; hsa-mir-6809-5p ; hsa-mir-571 ; hsa-mir-4715-5p ; hsa-mir-3141
Nearest miRNA
hsa-mir-10398/Upstream/1515354; hsa-mir-1202/Downstream/10769473;
Nearest TSS
ENST00000381078/Upstream/3821; ENST00000431865/Downstream/57116;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/4380, chr6-CpG: 477/Downstream/258053
Upstream sequence
CAAAGGATTTTAGAGGGATATTCAATATGGGGCTTGTTAAATTTGAGGCATTTATTATAGTTCCAGGTAAATAAGTCTAGTTAGTTGTAGGACACTTGGG
Downstream sequence
GATCTGAGACTAAGAAAGAAAATATGAGGTATTGGGAGCCATGAGAATAGAAGAATGAGCCTGGGAATATATGTGTAGGGTGAAAAGAGCCTgtggcttg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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