Basic Information
VIS ID
TVIS44019640
Fusion event
HTLV-1-ARMC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
109266719/108945516 (Hg38)
End
109266719/108945516 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6F
Target gene
ARMC2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-155-5p
Nearest miRNA
hsa-mir-10398/Upstream/2161296; hsa-mir-1202/Downstream/10123531;
Nearest TSS
ENST00000381078/Upstream/21413; ENST00000481850/Downstream/13944;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/96616, chr6-CpG: 91/Downstream/63566
Upstream sequence
TGATCAAAAAGAACAACCTTTGTCTACATTCCTATCACATGTGTCCATTGACCATTTAACTCTCTCCACGTTTAGATACGGTTAATTTCTTGTTTCTTTT
Downstream sequence
ACCACAGAGCTTCCAGATGCAGCAGGACTGTCGTCAGAGCCTTTGCAAACCCTGGGAACTGCCAGACTCATTCTTGGTTGTGCTGCTTTTAAAGTCCTAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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