Basic Information
VIS ID
TVIS44019643
Fusion event
HTLV-1-NEDD9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
11295721/11295488 (Hg38)
End
11295721/11295488 (Hg38)
Orient
-
Location type
Intronic
Target gene
NEDD9
miRNAs that regulate target gene
hsa-mir-18a-5p ; hsa-mir-145-5p ; hsa-mir-30c-5p ; hsa-mir-218-5p ; hsa-mir-6803-5p ; hsa-mir-6751-5p ; hsa-mir-642a-5p ; hsa-mir-4477a ; hsa-mir-5682 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6835-5p ; hsa-mir-5702 ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-6871-3p ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-4506 ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-3912-3p
Nearest miRNA
hsa-mir-3691/Upstream/855694; hsa-mir-10398/Downstream/4846068;
Nearest TSS
ENST00000381078/Upstream/62806; ENST00000419796/Downstream/86784;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/201054, chr6-CpG: 182/Downstream/241816
Nearest cancer related gene
NEDD9(OG, No orient, 0)
Upstream sequence
GAAGATAATGGTAAGTCCTTCCACTCACTTGAGGAAAGTAAATTTCAGATTtgtagtggacactggggtccatgacctgacaccccacttcaggcttagt
Downstream sequence
caatcattctgtcagctatggaagggttggcacctagcagcttgcttcagagtcccctcttgagattgtccccagctgaggcacagcacacctcctccct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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