Basic Information
VIS ID
TVIS44019647
Fusion event
HTLV-1-RWDD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
116894178/116573015 (Hg38)
End
116894178/116573015 (Hg38)
Orient
-
Location type
Intronic
Target gene
RWDD1
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-411-5p ; hsa-mir-4662a-5p ; hsa-mir-7852-3p ; hsa-mir-3668 ; hsa-mir-5680 ; hsa-mir-450b-5p ; hsa-mir-4474-5p ; hsa-mir-1251-3p ; hsa-mir-202-3p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-942-5p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-877-3p ; hsa-mir-4775 ; hsa-mir-4705 ; hsa-mir-590-3p ; hsa-mir-34b-3p
Nearest miRNA
hsa-mir-10398/Upstream/9788795; hsa-mir-1202/Downstream/2496032;
Nearest TSS
ENST00000381078/Upstream/1452; ENST00000468204/Downstream/7192;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1244, chr6-CpG: 53/Downstream/107920
Upstream sequence
AGCAGTACATCTGTGCTGTGAGGATGTTAAGGGGATGAGTGAAGAGGGGTTTGAGAGTGTCATTAACTGGGTGAGTGTGTATGGAGTCTGGCTCCCTTCT
Downstream sequence
CTATCCTTGCTTATATGTGTATGTCTAAAATAGAATATAGGGTCAGTTGTTGGATATATTCTTAATCATGTTTGGTCATTTCCAGTACTTTGGAAACATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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