Basic Information
VIS ID
TVIS44019657
Fusion event
HTLV-1-AHI1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
135676932/135355794 (Hg38)
End
135676932/135355794 (Hg38)
Orient
+
Location type
Intronic
Target gene
AHI1
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-218-5p ; hsa-mir-619-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6778-3p ; hsa-mir-150-5p ; hsa-mir-6814-5p ; hsa-mir-4761-5p ; hsa-mir-6504-3p ; hsa-mir-3159 ; hsa-mir-4735-3p ; hsa-mir-4438 ; hsa-mir-18b-5p ; hsa-mir-18a-5p ; hsa-mir-331-5p ; hsa-mir-636 ; hsa-mir-3618 ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-1283 ; hsa-mir-455-5p ; hsa-mir-4678 ; hsa-mir-4517
Nearest miRNA
hsa-mir-10398/Upstream/116538; hsa-mir-1202/Downstream/3079419;
Nearest TSS
ENST00000381078/Upstream/32415; ENST00000579057/Downstream/55714;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/172521, chr6-CpG: 84/Downstream/141569
Nearest cancer related gene
AHI1(OG, No orient, 0)
Upstream sequence
ttgaggccagcctgacctacacggtgaaaccccatctctactaaaaatacaaaaattagctgggcgtggttgtggacgcctgtaatcccagctacttagg
Downstream sequence
aggctgaggcaggagaactgcttgaacccgggagacggacattgcagtgaactgagattgcgccacggcactccagcctgggcaacagagcgagactctg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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