Basic Information
VIS ID
TVIS44019658
Fusion event
HTLV-1-OLIG3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
137814783/137493646 (Hg38)
End
137814783/137493646 (Hg38)
Orient
-
Location type
Exonic
Target gene
OLIG3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-4729 ; hsa-mir-5696 ; hsa-mir-1324 ; hsa-mir-664a-3p ; hsa-mir-506-5p ; hsa-mir-6074 ; hsa-mir-892c-5p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6818-3p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-3615 ; hsa-mir-6845-3p ; hsa-mir-136-5p ; hsa-mir-1251-5p ; hsa-mir-517-5p
Nearest miRNA
hsa-mir-10398/Upstream/2254390; hsa-mir-1202/Downstream/941567;
Nearest TSS
ENST00000381078/Upstream/274197; ENST00000642830/Downstream/604;
Nearest CpG islands
chr6-CpG: 81/Target, None/Upstream, None/Downstream
Upstream sequence
GGTGCCGATGGCGGGAAGTGAGGCGGCGGACAGCGGTGACGAGGCGTTGCCAGATGAGAGCGCGCCGCCCAAGATGGGGTGCACCGGGTGCACGGAGTTG
Downstream sequence
GCCGCGTGCGCGGGGTGGCCGGCCGAGTGGCCCACGGTCCCGCAGTGAAAGGCCGAGTGGTGGCCCCCATAGATCTCGCCAACCAGCCTCTTCATCTCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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