Basic Information
VIS ID
TVIS44019668
Fusion event
HTLV-1-TIAM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
155535412/155214278 (Hg38)
End
155535412/155214278 (Hg38)
Orient
-
Location type
Intronic
Target gene
TIAM2
miRNAs that regulate target gene
hsa-mir-106a-3p ; hsa-mir-129-5p ; hsa-mir-3680-3p ; hsa-mir-3692-3p ; hsa-mir-4436b-5p ; hsa-mir-450b-5p ; hsa-mir-507 ; hsa-mir-557 ; hsa-mir-6509-3p
Nearest miRNA
hsa-mir-10398/Upstream/360842; hsa-mir-1202/Downstream/732519;
Nearest TSS
ENST00000381078/Upstream/3052; ENST00000546145/Downstream/2359;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/218215, chr6-CpG: 16/Downstream/4563
Upstream sequence
cattctcagctcctgctggctccatggaacgcacagcgctggccgtgcctcccccggtgcagccggcatcatcgcagtgactgttccagatgggccaccg
Downstream sequence
ctgccatcaAGACCACCAGGAGCCAGGCACATGGCACATCCTTTGGAGGAACCATGTGGCATACCTTTTGGGGGTTGGTGACATCCCCTGTGTGTGAGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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