Basic Information
VIS ID
TVIS44019677
Fusion event
HTLV-1-SMOC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q27
Reference genome
GRCh37/hg19
Start
169044101/168643421 (Hg38)
End
169044101/168643421 (Hg38)
Orient
-
Location type
Intronic
Target gene
SMOC2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-3156-5p ; hsa-mir-1299 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6836-5p ; hsa-mir-5002-3p ; hsa-mir-6132 ; hsa-mir-6128 ; hsa-mir-875-3p ; hsa-mir-1205 ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-8055 ; hsa-mir-6807-5p ; hsa-mir-6124 ; hsa-mir-3148 ; hsa-mir-3121-5p ; hsa-mir-3688-3p ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-10398/Upstream/1645509; hsa-mir-4644/Downstream/1687340;
Nearest TSS
ENST00000381078/Upstream/202270; ENST00000417208/Downstream/9538;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/69992, chr6-CpG: 14/Downstream/152451
Upstream sequence
cttgtttctggactcataagacctcctgggttttgggcccctgtcagttcctcaactttgttccctaggaccatccttcctgccccactcgacacaccct
Downstream sequence
ggtatcctcagggcctcaggaatgccacactgcctgggacgcagggtcttcgtgggccttccctgtgcccccagcactctcctcccTGTTCCAAATGGCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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