Basic Information
VIS ID
TVIS44019682
Fusion event
HTLV-1-DCDC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
24224730/24224502 (Hg38)
End
24224730/24224502 (Hg38)
Orient
+
Location type
Intronic
Target gene
DCDC2
miRNAs that regulate target gene
hsa-mir-328-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-5692a ; hsa-mir-592 ; hsa-mir-7106-3p ; hsa-mir-581 ; hsa-mir-1288-5p ; hsa-mir-501-5p ; hsa-mir-500b-5p ; hsa-mir-362-5p ; hsa-mir-34c-3p
Nearest miRNA
hsa-mir-3691/Upstream/5652622; hsa-mir-10398/Downstream/2923124;
Nearest TSS
ENST00000381078/Upstream/19199; ENST00000274766/Downstream/132401;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/98218, chr6-CpG: 56/Downstream/132989
Nearest cancer related gene
DCDC2(TSG, No orient, 0)
Upstream sequence
AGGGGTACAATGGTGCACAGAGGACAGAGCTGTTAAACACCTAAGATGAAGAGCTTACTAATATGATCTGCTCAGTGCTCTTTAACTGAAGCACTTGGTG
Downstream sequence
AGCGTGTGTGTGCATGTGGTGTGTACATGCATGTATATGTACACACACATATGTGGTGTGCACTGGTGCTCAAAACTCAAAACTGGGGTGGCAGAAGCCG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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