Basic Information
VIS ID
TVIS44019685
Fusion event
HTLV-1-WRNIP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p25.2
Reference genome
GRCh37/hg19
Start
2779369/2779135 (Hg38)
End
2779369/2779135 (Hg38)
Orient
-
Location type
Intronic
Target gene
WRNIP1
miRNAs that regulate target gene
hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-6720/Upstream/1388724; hsa-mir-10398/Downstream/74896;
Nearest TSS
ENST00000381078/Upstream/10362; ENST00000437718/Downstream/58864;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/12594, chr6-CpG: 55/Downstream/62404
Upstream sequence
GATACCCTCGACACTCATAAGATACAGGGCGATAACCTGGTGACTTAGGAGCCCCAGTCAGTTCGTAGTCTTGATGATGCTTAAGCACATTGACAAAGGT
Downstream sequence
GAGAATAAGAGGCAAAGGCCTTGAACTCTTCAGTGTCCTTGCTGAGAAGTATGAGTTTCTAAGACATGTGCAGAACAAGAAGTATGCAGCCTGAGTGTGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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