Basic Information
VIS ID
TVIS44019694
Fusion event
HTLV-1-SLC22A23 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p25.2
Reference genome
GRCh37/hg19
Start
3455031/3454797 (Hg38)
End
3455031/3454797 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLC22A23
miRNAs that regulate target gene
hsa-mir-378a-3p ; hsa-mir-3127-5p ; hsa-mir-4276 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-103a-2-5p ; hsa-mir-4772-5p ; hsa-mir-383-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-5190 ; hsa-mir-5094 ; hsa-mir-6760-5p ; hsa-mir-6873-5p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-20a-5p ; hsa-mir-526b-3p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-520b ; hsa-mir-520c-3p ; hsa-mir-520d-3p ; hsa-mir-520e ; hsa-mir-520a-3p ; hsa-mir-520f-3p
Nearest miRNA
hsa-mir-4645/Upstream/600690; hsa-mir-10398/Downstream/1693436;
Nearest TSS
ENST00000381078/Upstream/9784; ENST00000603791/Downstream/1246;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/195293, chr6-CpG: 235/Downstream/1030
Upstream sequence
GCAGCAGGGGCAGCTCAGTCAGACAGTTCCCACAGGACAGAGCATTTCTGGCCAGGTTGGTACAAGATTAAAACAATGATTATGATGATGTAAGAGTTTA
Downstream sequence
TCTTACACATCCATGAGCTACAACTGTTAACCAATGCACACGGGGGGAGGAGGTTACATGCACATTGACTATTTAAAACTGTCCAATTTCATACATTTCG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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