Basic Information
VIS ID
TVIS44019699
Fusion event
HTLV-1-RAB44 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
36690132/36722355 (Hg38)
End
36690132/36722355 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA6H
Target gene
RAB44
miRNAs that regulate target gene
hsa-mir-4535 ; hsa-mir-4776-5p ; hsa-mir-711 ; hsa-mir-6859-3p ; hsa-mir-361-3p ; hsa-mir-4691-3p ; hsa-mir-22-3p ; hsa-mir-449b-3p
Nearest miRNA
hsa-mir-1236/Upstream/99843; hsa-mir-10398/Downstream/833010;
Nearest TSS
ENST00000381078/Upstream/24545; ENST00000355190/Downstream/35026;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/37997, chr6-CpG: 147/Downstream/116750
Upstream sequence
TCGGAACTCCCCCAGCAAGACTCTCTGCTTGTTTCTCTCCCATCTGCCACACCACAGGCTCAGGTGGAAGCAGAAGGCCCCACTCCTGGAAAATCGGCAC
Downstream sequence
CTCCAAGGGGCTCTCCTCCCAGGGGGGCTCAGCCTGGGGCTGGAGCAGGACCCCAGGAACCCACGCAAACCCCTCCCACCATGGCTGAGCAGGAAGCCCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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