Basic Information
VIS ID
TVIS44019702
Fusion event
HTLV-1-PXDC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p25.2
Reference genome
GRCh37/hg19
Start
3724976/3724742 (Hg38)
End
3724976/3724742 (Hg38)
Orient
+
Location type
Intronic
Target gene
PXDC1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-192-5p ; hsa-mir-218-5p ; hsa-mir-4322 ; hsa-mir-4296 ; hsa-mir-4265 ; hsa-mir-642a-5p ; hsa-mir-4417 ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-6721-5p ; hsa-mir-6827-5p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-1225-3p ; hsa-mir-134-3p ; hsa-mir-4655-3p ; hsa-mir-6803-3p ; hsa-mir-4323 ; hsa-mir-140-3p ; hsa-mir-4758-3p ; hsa-mir-873-5p
Nearest miRNA
hsa-mir-4645/Upstream/870635; hsa-mir-10398/Downstream/1423491;
Nearest TSS
ENST00000381078/Upstream/99995; ENST00000603791/Downstream/14152;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/267013, chr6-CpG: 233/Downstream/25812
Upstream sequence
GAGCCACCTCGGGGCTGCCTCCTGTGCCGCCCCCAGTGACTGAAGGTGGCCCTGGCCCGTGGACAACTGTGGGAACTCAGCCATCTCTGGAAAGCTTTGC
Downstream sequence
CATGACCAAGATGACTGCACAGTCCAGGCCCCTGGCCGGACACACAACAAGGCAGGGCGAGCATATGTCCCCCACAAACCTAGTACATCGTGCGAATCCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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