Basic Information
VIS ID
TVIS44019703
Fusion event
HTLV-1-ZFAND3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
38037094/38069318 (Hg38)
End
38037094/38069318 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
ZFAND3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6731-3p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-7844-5p ; hsa-mir-3199 ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-4521 ; hsa-mir-4709-3p ; hsa-mir-488-3p ; hsa-mir-541-5p ; hsa-mir-5681a ; hsa-mir-6730-5p ; hsa-mir-6768-3p ; hsa-mir-7854-3p ; hsa-mir-8052
Nearest miRNA
hsa-mir-1236/Upstream/513896; hsa-mir-10398/Downstream/1004996;
Nearest TSS
ENST00000381078/Upstream/7707; ENST00000440482/Downstream/19013;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/249544, chr6-CpG: 77/Downstream/570111
Upstream sequence
ACAGGCTGGTTTCTTCTAGTAAAGCATTTAGAAAATATTGCCTATTAAAAAATATTTTATGACTTCCTGCTGGGCTGGTTTTAAGTGAAATATGGTGGGG
Downstream sequence
AGATTTATTTACAGTTCTCTGTGTGTGTGTCTTTCTCTTTGCTTTTCTCTAATGAAGCTCAAAGCATCAGGCCATTTATCAGAGATAATTATACAACAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate