Basic Information
VIS ID
TVIS44019711
Fusion event
HTLV-1-PTK7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
43100908/43133170 (Hg38)
End
43100908/43133170 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
PTK7
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-7-5p ; hsa-mir-193b-3p ; hsa-mir-324-5p ; hsa-mir-92a-3p ; hsa-mir-218-5p ; hsa-mir-190a-3p ; hsa-mir-6083 ; hsa-mir-5689 ; hsa-mir-3141 ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-1265 ; hsa-mir-185-5p ; hsa-mir-2110 ; hsa-mir-2392 ; hsa-mir-3154 ; hsa-mir-3915 ; hsa-mir-3928-3p ; hsa-mir-4271 ; hsa-mir-4306 ; hsa-mir-4428 ; hsa-mir-4644 ; hsa-mir-4725-3p ; hsa-mir-491-5p ; hsa-mir-651-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6770-5p ; hsa-mir-6780b-5p ; hsa-mir-6863 ; hsa-mir-92a-2-5p
Nearest miRNA
hsa-mir-10398/Upstream/1399560; hsa-mir-10524/Downstream/301372;
Nearest TSS
ENST00000381078/Upstream/644; ENST00000470471/Downstream/5383;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/55851, chr6-CpG: 159/Downstream/37803
Nearest cancer related gene
PTK7(OG, No orient, 0)
Upstream sequence
cccacaaggtggttggaaaggtcaaatgaagtagatgaaaatgatttTTCTTTTTTTCTTTTTTGGGAGGTAATAGTGGACAAAATTATAGGTGATTTTT
Downstream sequence
AATTTGTTTTAGTTTGTTATGCTTTCCAAATTTCTTTACTAAACATATTACTTATGAAAAAAAAGAGGGGGAGAAAAGCAAGACATATGACTGAAAGTAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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