Basic Information
VIS ID
TVIS44019723
Fusion event
HTLV-1-DST integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
56582136/56717338 (Hg38)
End
56582136/56717338 (Hg38)
Orient
+
Location type
Intronic
Target gene
DST
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-32-5p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-218-5p ; hsa-mir-26a-5p ; hsa-mir-3130-3p ; hsa-mir-485-3p ; hsa-mir-539-3p ; hsa-mir-136-5p ; hsa-mir-127-5p ; hsa-mir-432-5p ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-7156-3p ; hsa-mir-500a-3p ; hsa-mir-6882-3p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-6804-3p ; hsa-mir-1468-3p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-545-3p ; hsa-mir-8063 ; hsa-mir-548p ; hsa-mir-4460 ; hsa-mir-4662a-5p ; hsa-mir-3119 ; hsa-mir-140-5p ; hsa-mir-6718-5p ; hsa-mir-203b-5p ; hsa-mir-553
Nearest miRNA
hsa-mir-10398/Upstream/3440267; hsa-mir-10524/Downstream/672794;
Nearest TSS
ENST00000381078/Upstream/24035; ENST00000426453/Downstream/68541;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/174210, chr6-CpG: 107/Downstream/125923
Upstream sequence
tccctggcaagcacagttcacaatagggttcacactcttatgagaatctaatggcactgctgatctgacaggaggtggagctcaggtgataatgcttgtt
Downstream sequence
cactggccactcacctcctgctgtaacaggccacagacagaaactggtctgtggcccaggggttggaaacccctggtttaaatgataatagccattcccc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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