Basic Information
VIS ID
TVIS44019735
Fusion event
HTLV-1-LMBRD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
70498218/69788326 (Hg38)
End
70498218/69788326 (Hg38)
Orient
-
Location type
Intronic
Target gene
LMBRD1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10398/Upstream/12398114; hsa-mir-10524/Downstream/1588634;
Nearest TSS
ENST00000381078/Upstream/555292; ENST00000478620/Downstream/2339;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1153172, chr6-CpG: 53/Downstream/8074
Upstream sequence
TCAAACATGCTCAATTCTAAACTAAAAAAATCTCCGATTCAAACAATAATTATACCAGGGATAATTATATGACCTCTATACATCAGAATACACACATATA
Downstream sequence
CATATATATCATTATCTATTTAAACTTAACAGCTTTCAGAAAGAAAAATATCCTAGAAATTTATAATTATGTACTGTACATTTGGAAGTATACTACACTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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