Basic Information
VIS ID
TVIS44019745
Fusion event
HTLV-1-CGAS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
74144651/73434928 (Hg38)
End
74144651/73434928 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
CGAS
miRNAs that regulate target gene
hsa-mir-548aw ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-1277-5p ; hsa-mir-1273d ; hsa-mir-5096 ; hsa-mir-5587-5p ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-6801-5p ; hsa-mir-8082 ; hsa-mir-4653-3p ; hsa-mir-4534 ; hsa-mir-1273f ; hsa-mir-4716-5p ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-4781-3p ; hsa-mir-6514-5p ; hsa-mir-513b-5p ; hsa-mir-4683 ; hsa-mir-4767 ; hsa-mir-4786-5p ; hsa-mir-125b-2-3p ; hsa-mir-4457 ; hsa-mir-6888-5p ; hsa-mir-6502-3p ; hsa-mir-624-3p ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428
Nearest miRNA
hsa-mir-10398/Upstream/467175; hsa-mir-10524/Downstream/1993479;
Nearest TSS
ENST00000381078/Upstream/27963; ENST00000485082/Downstream/10757;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/39773, chr6-CpG: 91/Downstream/16435
Upstream sequence
gtagagacggggttttgccatgttggccagggtggtttcgaactcttgatttcaggtgatctgcccacctcggcctcccaaagtgctgggattacaggca
Downstream sequence
agacccactgtgcccagcagatatagcccttagctaacaataatatatcaatattggtttattaattattaaatgtattgtattaatgtgagatattaat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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