Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene799254088010664780346270801058018010760180126243801276508012815380129257801227048012285380135839
Basic Information
VIS ID
TVIS44019754
Fusion event
HTLV-1-BCKDHB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
80845556/80135839 (Hg38)
End
80845556/80135839 (Hg38)
Orient
+
Location type
Intronic
Target gene
BCKDHB
miRNAs that regulate target gene
hsa-mir-1-3p
Nearest miRNA
hsa-mir-10398/Upstream/1596530; hsa-mir-1202/Downstream/10176903;
Nearest TSS
ENST00000381078/Upstream/8570; ENST00000468520/Downstream/67263;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/28870, chr6-CpG: 231/Downstream/1615577
Nearest cancer related gene
BCKDHB(OG, No orient, 0)
Upstream sequence
ttgtggtgcaattattaccaccatccatcaccagaacttttttcatcttacaaaactgaaacactataaccatctaacaataactccccattttctctcc
Downstream sequence
aacagtccctggcaagaacccattctactttctatctctatgaatttgactgttccttatgtgagtggaatcatttagtatttgtccttttgtgactgcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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