Basic Information
VIS ID
TVIS44019762
Fusion event
HTLV-1-ZNF292 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
87885721/87176003 (Hg38)
End
87885721/87176003 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF292
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-196a-3p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-3925-5p ; hsa-mir-3120-3p ; hsa-mir-32-3p ; hsa-mir-1273g-3p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-508-5p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-mir-6873-3p ; hsa-mir-4795-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-3675-3p ; hsa-mir-7151-5p ; hsa-mir-5003-3p
Nearest miRNA
hsa-mir-10398/Upstream/8636694; hsa-mir-1202/Downstream/3136739;
Nearest TSS
ENST00000381078/Upstream/20382; ENST00000485016/Downstream/37711;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/19944, chr6-CpG: 30/Downstream/146436
Nearest cancer related gene
ZNF292(TSG, No orient, 0)
Upstream sequence
TTTGTGACCCCACCTAGACTTACCTTCAATTTATTTACACTACGCTCCTGGTTCTACGTTTGTGACTGTTTATTGTCTTTACTCCTTTCACCTTCTGGAA
Downstream sequence
GGTAAATGATAGCTATTATTAATATATTAAAGAGGACTAGATCCAAAAGTTTGTAGTATATGTGTGGTGGGGGGGGCTTTCCCTCAtagggaagaaaaag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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