Basic Information
VIS ID
TVIS44019767
Fusion event
HTLV-1-FUT9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q16.1
Reference genome
GRCh37/hg19
Start
96485975/96038099 (Hg38)
End
96485975/96038099 (Hg38)
Orient
-
Location type
Intronic
Target gene
FUT9
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-7703 ; hsa-mir-6729-5p ; hsa-mir-4649-5p ; hsa-mir-1273a ; hsa-mir-661 ; hsa-mir-767-5p ; hsa-mir-4486 ; hsa-mir-4793-3p ; hsa-mir-3130-3p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-939-3p ; hsa-mir-6850-3p ; hsa-mir-1273g-3p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-186-3p ; hsa-mir-576-3p ; hsa-mir-3121-3p
Nearest miRNA
hsa-mir-10398/Upstream/4516362; hsa-mir-1202/Downstream/1986432;
Nearest TSS
ENST00000381078/Upstream/22115; ENST00000461673/Downstream/483496;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/21839, chr6-CpG: 61/Downstream/483536
Upstream sequence
CCTAATCCCTGCATCTTCACTGCAGGTGTGTGGTGCCTTGAACAGAGAGTGATGCTTCGGAGCGTTGCCACAAGGTCAATGGCTCCTAAGTAAGATGTAT
Downstream sequence
AAGATGACAACAGACAACTTCAGGTAAAAGAAATACAAAATATGTAATTACAACACTTTTAGGAAGGCATGAGTTTCCATTTAATTTCCAATTATGGAAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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