Basic Information
VIS ID
TVIS44019770
Fusion event
HTLV-1-FBXL13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
102570948/102930501 (Hg38)
End
102570948/102930501 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
FBXL13
miRNAs that regulate target gene
hsa-mir-4477a ; hsa-mir-9-3p ; hsa-mir-590-5p ; hsa-mir-21-5p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-5096 ; hsa-mir-3149 ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-197-3p ; hsa-mir-4775 ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-4735-5p ; hsa-mir-4716-5p ; hsa-mir-4781-3p ; hsa-mir-6890-5p ; hsa-mir-941 ; hsa-mir-590-3p ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426
Nearest miRNA
hsa-mir-10525/Upstream/458970; hsa-mir-10399/Downstream/11722844;
Nearest TSS
ENST00000635602/Upstream/17496; ENST00000455453/Downstream/2729;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/181035, chr7-CpG: 90/Downstream/144158
Nearest cancer related gene
FBXL13(TSG, No orient, 0)
Upstream sequence
tccttctaccactctctaagacacttttctggaaagatcagtttatgcctaatgcctcaccttctgacctcttctccacttcacaattcattgcaagtag
Downstream sequence
atttctgctccaatatcccactgaaactgttgaagcaataattggcagtcccttctgattctcaaatctacaatgcattgttcagtccttttcttacctg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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