VISDB Viral Integration Site DataBase

VIS ID

TVIS44019785

Fusion event

HTLV-1-MKLN1 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr7

Cytoband

q32.3

Reference genome

Start

End

130830766/131146007 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-128-3p ; hsa-mir-124-3p ; hsa-mir-101-3p ; hsa-mir-27a-3p ; hsa-mir-320b ; hsa-mir-324-5p ; hsa-mir-100-5p ; hsa-mir-142-3p ; hsa-mir-16-1-3p ; hsa-mir-144-3p ; hsa-mir-376c-5p ; hsa-mir-376b-5p ; hsa-mir-513a-5p ; hsa-mir-651-3p ; hsa-mir-1252-5p ; hsa-mir-3165 ; hsa-mir-5002-5p ; hsa-mir-6880-5p ; hsa-mir-8071 ; hsa-mir-142-5p ; hsa-mir-5590-3p ; hsa-mir-4496 ; hsa-mir-511-3p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-155-5p ; hsa-mir-5191 ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-3154 ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-340-5p ; hsa-mir-8054 ; hsa-mir-548l ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548b-5p ; hsa-mir-548bb-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-548c-3p ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-3194-3p ; hsa-mir-6499-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-6733-3p ; hsa-mir-143-5p ; hsa-mir-106a-3p ; hsa-mir-8055 ; hsa-mir-374b-3p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-889-3p ; hsa-mir-548au-3p ; hsa-mir-449b-5p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-34a-5p ; hsa-mir-3140-3p ; hsa-mir-4686 ; hsa-mir-575 ; hsa-mir-4676-5p ; hsa-mir-6858-3p ; hsa-mir-3529-3p ; hsa-mir-5583-3p ; hsa-mir-4517

Nearest miRNA

hsa-mir-10525/Upstream/268468; hsa-mir-10399/Downstream/1888853;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/37993, chr7-CpG: 74/Downstream/181694

Upstream sequence

GTGACAGAAGTTCAAACACTAGAGTGAGGAAGTGAGGAGAATAGATTTGTTTataatagcaaacacatagtgagtgtgtactgtatggcaaacaccataa

Downstream sequence

tacgtgattaatgaggttgtcatttctaatacatcaatcccactagctcattttacagatgagaaagtgaggcttagagggattaagcaatttgcccaag