Basic Information
VIS ID
TVIS44019789
Fusion event
HTLV-1-DENND2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q34
Reference genome
GRCh37/hg19
Start
140266170/140566370 (Hg38)
End
140266170/140566370 (Hg38)
Orient
+
Location type
Intronic
Target gene
DENND2A
miRNAs that regulate target gene
hsa-mir-185-5p
Nearest miRNA
hsa-mir-10399/Upstream/1522213; hsa-mir-11400/Downstream/1908157;
Nearest TSS
ENST00000635602/Upstream/10657; ENST00000498423/Downstream/36142;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/86703, chr7-CpG: 135/Downstream/73827
Upstream sequence
atccgcccacttcggcctcccaaagtactgggattacaggtgtgagtcaccgcgcctggcctcctttacattcttaataaatttgctttcattttaccct
Downstream sequence
gctgactcgccctgaattctttcttgtgtgagatccaagaaccctctctagaggtctggattgagatcccctgcctgtaacaAAAGGAAGGGACATACAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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