Basic Information
VIS ID
TVIS44019797
Fusion event
HTLV-1-DGKB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
14956336/14916711 (Hg38)
End
14956336/14916711 (Hg38)
Orient
+
Location type
Intronic
Target gene
DGKB
miRNAs that regulate target gene
hsa-mir-3121-3p ; hsa-mir-495-3p ; hsa-mir-551b-5p ; hsa-mir-5688 ; hsa-mir-7-1-3p ; hsa-mir-7-2-3p ; hsa-mir-95-5p
Nearest miRNA
hsa-mir-339/Upstream/7849666; hsa-mir-10399/Downstream/3210509;
Nearest TSS
ENST00000635602/Upstream/13345; ENST00000445093/Downstream/58066;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/925123, chr7-CpG: 17/Downstream/1482786
Nearby gene
DGKB(-75261) ;
Upstream sequence
tgtgtgcacctaaaaacagagcattaaagaacatgaggcaaaaaatgatagaaagagaaatagaaaattcattattatagttggaaagttcaacacctct
Downstream sequence
ataacagctattgacagctccaacaggcagaaaatctgtaaggatacaattgaactgaatatcaccatcaatcaactatatctaattgacatttataaaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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