Basic Information
VIS ID
TVIS44019799
Fusion event
HTLV-1-chr7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
149741109/150044020 (Hg38)
End
149741109/150044020 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
ACTR3C ; LOC100134040
miRNAs that regulate target gene
hsa-mir-379-3p ; hsa-mir-487a-3p ; hsa-mir-127-3p ; hsa-mir-539-3p
Nearest miRNA
hsa-mir-10399/Upstream/2665899; hsa-mir-153-2/Downstream/1194401;
Nearest TSS
ENST00000635602/Upstream/2657; ENST00000495144/Downstream/18069;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/169720, chr7-CpG: 189/Downstream/3293
Nearby gene
ATP6V0E2(+163308) ;
Upstream sequence
AGGTGGAGGAAAAAAGATTGGTTGGTTGTCGAAGACATAGCGGATGATGAAATTGGCCCTTCCAAGGCTGGTGGACATCATGGGTGGTGATTTGCTAATG
Downstream sequence
TCTCCCAGTTTTAACCAATTTGCTGCTTTAAAATCCTGTTGTCATCACATTTGTATTGCAAAGAAGCCACATGTCACTGAAAATGAAGGATACAGGAACA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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