Basic Information
VIS ID
TVIS44019810
Fusion event
HTLV-1-HDAC9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
18653569/18613946 (Hg38)
End
18653569/18613946 (Hg38)
Orient
+
Location type
Intronic
Target gene
HDAC9
miRNAs that regulate target gene
hsa-mir-342-3p ; hsa-mir-8485 ; hsa-mir-29a-5p
Nearest miRNA
hsa-mir-1302-6/Upstream/486637; hsa-mir-10399/Downstream/1091412;
Nearest TSS
ENST00000635602/Upstream/104633; ENST00000483142/Downstream/179213;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/526560, chr7-CpG: 34/Downstream/492303
Upstream sequence
GACCCCATTGTCCAACCCATGCTCCTTAAAATTTTAACCTCATGGGCTGCCCTTTCATTCATCTGCTTTACCTCTCTATTTTTACCACCGCGTCCTTTAA
Downstream sequence
ATATGAAGCTCATGAAACCTGAGGTTCCTGAGGTTCCTAAAGTTGCATTGTCTCTTCTATTTTTTTAACTTTTCTATTTCAATTGTCACCATCTTAAAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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