Basic Information
VIS ID
TVIS44019813
Fusion event
HTLV-1-MAD1L1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
2074039/2034404 (Hg38)
End
2074039/2034404 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
MAD1L1
miRNAs that regulate target gene
hsa-mir-149-5p ; hsa-mir-20a-5p
Nearest miRNA
hsa-mir-339/Upstream/190151; hsa-mir-10399/Downstream/223111;
Nearest TSS
ENST00000635602/Upstream/53613; ENST00000454650/Downstream/45609;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/13908, chr7-CpG: 24/Downstream/15554
Nearest cancer related gene
MAD1L1(TSG, No orient, 0)
Upstream sequence
ctcccgggttcaagcgattctcctgcctcagcctcctgagtaggtgggactacaggcacacaccaccacgcccagctaattttttgtattttagtagaga
Downstream sequence
cggggtttcaccgtgttgcccaggctggtccgaactcctgagctcaggcaatccacccgtctcagcctcccaaagtgctaggattacaggcatgagccac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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