Basic Information
VIS ID
TVIS44019819
Fusion event
HTLV-1-GNA12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
2771011/2731377 (Hg38)
End
2771011/2731377 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA7B
Target gene
GNA12
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-98-5p ; hsa-mir-93-5p ; hsa-mir-149-5p ; hsa-mir-23b-3p ; hsa-mir-218-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-4653-3p ; hsa-mir-4424 ; hsa-mir-432-5p ; hsa-mir-335-5p ; hsa-mir-1266-5p ; hsa-mir-211-3p ; hsa-mir-3664-3p ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-4518 ; hsa-mir-6754-5p ; hsa-mir-7-5p ; hsa-mir-8087 ; hsa-mir-9500
Nearest miRNA
hsa-mir-339/Upstream/204232; hsa-mir-10399/Downstream/2057188;
Nearest TSS
ENST00000635602/Upstream/28847; ENST00000433945/Downstream/29075;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/12754, chr7-CpG: 16/Downstream/3433
Nearest cancer related gene
GNA12(OG, No orient, 0)
Upstream sequence
AAGTGGTGGAAGAGTGGCTTGCTGCGGTTCCGTCTCTTCCTGTCGAAGCACTGGACCAGGTAGCGCTGGACGTCCTCCAGCCTGTGCGGGTCGCCCCTGA
Downstream sequence
AGTCCGGGAAGTGCTTCTTGATGCTCACGGTCTTCACCTTCTCCACCAGGAGGTCCATCTTGTTGAGGAAGAGAATGATGGAGACGTTGAAGAAGAGCTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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