Basic Information
VIS ID
TVIS44019821
Fusion event
HTLV-1-NOD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
30477798/30438182 (Hg38)
End
30477798/30438182 (Hg38)
Orient
+
Location type
Intronic
Target gene
NOD1
miRNAs that regulate target gene
hsa-mir-1250-3p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-1183/Upstream/148292; hsa-mir-10399/Downstream/2294799;
Nearest TSS
ENST00000635602/Upstream/4768; ENST00000583191/Downstream/9795;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/152157, chr7-CpG: 68/Downstream/40189
Upstream sequence
GGTCAGAGACATTCCTGAAGACACAGTCTTCCAGGAGACAAAGAGCAGGAAGTACCTTCAGAAACCCCATCAGCAACGTTCCTGTCACATAAAGAGGACG
Downstream sequence
TTACCCAACCAAGCTCTGTGGCTACGGCCATCTTGGTGGACAGGTGCGGCGATAAAGCTGTATTCTGTCCCCTACAGCAGATCCGGAGAGTCTCTGGCTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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