Basic Information
VIS ID
TVIS44019830
Fusion event
HTLV-1-AOAH integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
36762801/36723196 (Hg38)
End
36762801/36723196 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7C
Target gene
AOAH
Nearest miRNA
hsa-mir-1183/Upstream/1782362; hsa-mir-10399/Downstream/196161;
Nearest TSS
ENST00000635602/Upstream/61896; ENST00000419326/Downstream/1253;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/332999, chr7-CpG: 136/Downstream/724555
Upstream sequence
GATTTTCCATTTGCAGCATGTAGCCATCAGACTTATCCTAGAGTTATTTTCCTGGCTTCTCAAGCTAGGATTGTATTTTGAGGTCTGCTCATTGAACAAT
Downstream sequence
TACTTACTACTCAGAGTTCTGAGTCTATGTGGCTCCATGGACTGTACCATCTAAATGCCACCACTATTATGAGAATTCCCATGTTATGAGAGCTACAATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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