Basic Information
VIS ID
TVIS44019851
Fusion event
HTLV-1-RADIL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
4844903/4805272 (Hg38)
End
4844903/4805272 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
RADIL
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-615-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4632-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-6746-3p ; hsa-mir-6849-3p
Nearest miRNA
hsa-mir-339/Upstream/16633; hsa-mir-10399/Downstream/690547;
Nearest TSS
ENST00000635602/Upstream/1204; ENST00000476992/Downstream/10061;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/12422, chr7-CpG: 84/Downstream/3348
Upstream sequence
ATGTGTGTGTGCGTGTGCACATACATGGCTCAGGGATGCGTCCCCACGGCTGTGTACCACCATTGCTCCCTTCCTGGGTAGCCATACAACAGGGGAGGCC
Downstream sequence
CCATCCTCCGGCTCCGTGAGGGAACGAGGGGGCCTTGGACCTGAGCCTGGAGTTTGGAACTTGGGCATGGACTCTCGGCTCCTTGACTCCCCCGCCGAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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