Basic Information
VIS ID
TVIS44019853
Fusion event
HTLV-1-ABCA13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
48319431/48279834 (Hg38)
End
48319431/48279834 (Hg38)
Orient
-
Location type
Exonic
Target gene
ABCA13
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1183/Upstream/3398034; hsa-mir-10399/Downstream/8675951;
Nearest TSS
ENST00000635602/Upstream/558; ENST00000484268/Downstream/33233;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/189470, chr7-CpG: 37/Downstream/174930
Upstream sequence
ACTTTTTGAGATTTTCATTAAAGCAACCACCGGAAAGAATGTCACATCAGAAAAAGAAGAGAGAACCAAGAAAGAGATGATTGACTTTCCTTATAGTTTC
Downstream sequence
AAACCATTTTTCTGTTTGGAGAAATACCTGGGAGGATTATTTGTATTGACTAAATACTGGCAACAAATCCCACTAACAGATCAAAGGTAATTAAAAAGCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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