Basic Information
VIS ID
TVIS44019879
Fusion event
HTLV-1-GALNT17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
70959760/71494775 (Hg38)
End
70959760/71494775 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
GALNT17
miRNAs that regulate target gene
hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6752-3p ; hsa-mir-3620-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-6500-3p ; hsa-mir-216b-3p ; hsa-mir-5582-5p ; hsa-mir-603
Nearest miRNA
hsa-mir-1183/Upstream/187005; hsa-mir-10399/Downstream/1203128;
Nearest TSS
ENST00000635602/Upstream/159226; ENST00000434423/Downstream/315720;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/361379, chr7-CpG: 187/Downstream/840997
Upstream sequence
AGCAGAGAGAAGCtgtattagtctgttctcatactgctaataaagacatacctgagactgggcaatttataaaggaaagaggtttaattgactcagttcc
Downstream sequence
acgtggctggggaggcctcacaatcacggctgaaggcaaatgagcaaagtcacgtcttacatggcagcaggcaggaaagcttgtgcgggggaactcccgt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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