Basic Information
VIS ID
TVIS44019885
Fusion event
HTLV-1-ELN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
73475488/74061158 (Hg38)
End
73475488/74061158 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
ELN
miRNAs that regulate target gene
hsa-mir-195-5p ; hsa-mir-2115-3p ; hsa-mir-6796-5p ; hsa-mir-6819-5p ; hsa-mir-6812-5p ; hsa-mir-6737-5p ; hsa-mir-6742-5p ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-3151-5p ; hsa-mir-491-5p ; hsa-mir-876-3p ; hsa-mir-4483 ; hsa-mir-1293 ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-4302 ; hsa-mir-181b-5p ; hsa-mir-29a-3p
Nearest miRNA
hsa-mir-1183/Upstream/349761; hsa-mir-10399/Downstream/130040;
Nearest TSS
ENST00000635602/Upstream/8307; ENST00000486361/Downstream/1126;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/205256, chr7-CpG: 96/Downstream/22356
Upstream sequence
AGCTCGGCTCCTGACCACTCCCCAACTTTTCTTTCTCCCCAGTACCTGGAGCCCTGGCTGCCGCTAAAGCAGCCAAATATGGTGAGTGCACCCCACAACC
Downstream sequence
ACTTGTGGCTCCCTTGCCACCACACCATCCCTGACAGCACAGGACTGGGGTGGTCACAATAGAAAAAGGCAGTTTCggccgggcgtggtggctcacacct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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