Basic Information
VIS ID
TVIS44019888
Fusion event
HTLV-1-MAGI2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
78046282/78416965 (Hg38)
End
78046282/78416965 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAGI2
miRNAs that regulate target gene
hsa-mir-655-3p ; hsa-mir-487b-3p ; hsa-mir-134-5p ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-3944-5p ; hsa-mir-5690 ; hsa-mir-4660 ; hsa-mir-4704-5p ; hsa-mir-3912-5p ; hsa-mir-487a-3p
Nearest miRNA
hsa-mir-10525/Upstream/2501696; hsa-mir-10399/Downstream/13787050;
Nearest TSS
ENST00000635602/Upstream/131159; ENST00000428298/Downstream/72826;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/376225, chr7-CpG: 26/Downstream/1035284
Upstream sequence
caggccttcaccagacactgaatctgctggcaccttgatcttggacttcacagcccctagaactgtgagaaataaatttctgctgcttaaaaaccacata
Downstream sequence
gtctgagaattttgttataatagcatgaatggactaagacaAGTGGTCACTGAAAGCCTCCAAATATATCCTCACTTTTCTTGCAAATAAAGGATAAAAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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