Basic Information
VIS ID
TVIS44019899
Fusion event
HTLV-1-GRM3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
86286657/86657341 (Hg38)
End
86286657/86657341 (Hg38)
Orient
+
Location type
Intronic
Target gene
GRM3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-487b-3p ; hsa-mir-129-5p ; hsa-mir-151a-3p ; hsa-mir-411-5p ; hsa-mir-4463 ; hsa-mir-4499 ; hsa-mir-4513 ; hsa-mir-6855-3p
Nearest miRNA
hsa-mir-10525/Upstream/10742072; hsa-mir-10399/Downstream/5546674;
Nearest TSS
ENST00000635602/Upstream/12496; ENST00000441140/Downstream/52758;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1470415, chr7-CpG: 45/Downstream/128963
Upstream sequence
aaacactttgcctgcccttagaatgtaaaatcttataggagagatgagatatgtgcatgtgtacctacagtaacaagAAAATTCAGGAGCTTGGCTGTGA
Downstream sequence
GACCCCTAAGTGGATAATAATATTTCTGTTTGACATAACTGTAGAAGGTATAATGAAAAATTTACTTCTGTCCTGGGCTCTAAAAAATTAGGATTTCAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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