Basic Information
VIS ID
TVIS44019908
Fusion event
HTLV-1-ATP5MF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99056403/99458780 (Hg38)
End
99056403/99458780 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
ATP5MF
miRNAs that regulate target gene
hsa-mir-125a-5p
Nearest miRNA
hsa-mir-10525/Upstream/49516; hsa-mir-10399/Downstream/634780;
Nearest TSS
ENST00000635602/Upstream/5093; ENST00000468705/Downstream/1685;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/19511, chr7-CpG: 19/Downstream/7020
Upstream sequence
GTGTACACTACACTGTCAGAAACAGCCTAGTCAGAGGCTGCCACCGACACCTCCCGCCAATCTCCCACCAGACAAGCTCCTCTCAAGCCTCAGAGCCGGA
Downstream sequence
ACAGCCATGCTTTTCTGGGGTACCAGattatcccactcaactcatttctctttctgcattggctactaggaaaatcgagccaaattttcacagtgtgctg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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