Basic Information
VIS ID
TVIS44019912
Fusion event
HTLV-1-chr8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
103747276/102735048 (Hg38)
End
103747276/102735048 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA8A
Nearest miRNA
hsa-mir-12123/Upstream/609533; hsa-mir-10400/Downstream/419566;
Nearest TSS
ENST00000518652/Upstream/79146; ENST00000522715/Downstream/70469;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/78415, chr8-CpG: 18/Downstream/3605
Nearby gene
KLF10(-79146) ;
Nearest cancer related gene
KLF10(TSG, -79146) ;
Upstream sequence
AAAGAAAGCTCGTAGGAAGCGACTTGGCTGATGGAGGGAAGGAATTCATCCCAGTCCAGGGATTATGGCAGTGACCCCATCAAGACTGGGCACTGGAATC
Downstream sequence
AGAGCGATCTGGCAGCCAGTGCAATGAAGTaataacaatggctgtcctttcctgaacgcctgctgtggccagaccccaagccaggaggcttgcagacatc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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