Basic Information
VIS ID
TVIS44019916
Fusion event
HTLV-1-ANGPT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
108468460/107456232 (Hg38)
End
108468460/107456232 (Hg38)
Orient
+
Location type
Intronic
Target gene
ANGPT1
Nearest miRNA
hsa-mir-12123/Upstream/2971767; hsa-mir-10400/Downstream/5187261;
Nearest TSS
ENST00000518652/Upstream/119710; ENST00000520037/Downstream/38763;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/797869, chr8-CpG: 92/Downstream/626395
Upstream sequence
CAGGCTCAAAAATGTCCTTTGTGTTGTTATGTTTAAGTCAACCAAACATGATTTGGTCAACGTTAAAACAGAAAGCTGGGTAACTGTTGAAGTCACAAAT
Downstream sequence
AGTTTTCTGCGAACTTGGACATCTTGAGCAAAGCTGAGATGTTTGCATAATCTTTTCTGTAGCAACAACATTCCACATGCATATTTCTCTTTAAAAAGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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