Basic Information
VIS ID
TVIS44019921
Fusion event
HTLV-1-GATA4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
11536690/11679181 (Hg38)
End
11536690/11679181 (Hg38)
Orient
+
Location type
Intronic
Target gene
GATA4
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-200b-3p ; hsa-mir-26b-5p ; hsa-mir-34a-5p ; hsa-mir-200c-3p
Nearest miRNA
hsa-mir-124-1/Upstream/643879; hsa-mir-10400/Downstream/1039951;
Nearest TSS
ENST00000518652/Upstream/2221; ENST00000526974/Downstream/13445;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/65441, chr8-CpG: 176/Downstream/77
Nearest cancer related gene
GATA4(TSG, No orient, 0)
Upstream sequence
GGAGAGGAGAGGTTTTAGGGTTAAATTCAAGCCATCAATCTCCAATTGTCTAAACACTACACGAAGTGGAGATTCGAGGCAATTATCCGAATAATTGCGG
Downstream sequence
GGGGGGGCACTTTCGCCTGAATTATCTAGATAAAAGAGCGACACAGGAGAATGTCAGTGGCCCTGAAGGCCCTGCCTCGGATCTCCACGGTCGCGCGAAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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