Basic Information
VIS ID
TVIS44019928
Fusion event
HTLV-1-COL14A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.12
Reference genome
GRCh37/hg19
Start
121320000/120307761 (Hg38)
End
121320000/120307761 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
COL14A1
miRNAs that regulate target gene
hsa-mir-324-5p ; hsa-mir-210-5p ; hsa-mir-3189-5p ; hsa-mir-4758-3p ; hsa-mir-5699-5p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-6752-3p ; hsa-mir-7108-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-548an
Nearest miRNA
hsa-mir-12123/Upstream/982496; hsa-mir-10400/Downstream/2908027;
Nearest TSS
ENST00000518652/Upstream/57014; ENST00000440844/Downstream/37685;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/182222, chr8-CpG: 24/Downstream/137352
Upstream sequence
aagatacataatcataatagttttcagggaaatgaaaattagaacaagaataaggtatattttcagcaatcaggttgataaaaatgtaaagtttgataat
Downstream sequence
attcagggttgattaagatttaaggaaacagggaccctcttaaactattggcagatcaataaactggcacagttagtttagagtacaatatgataatata
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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