Basic Information
VIS ID
TVIS44019936
Fusion event
HTLV-1-TG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
133980996/132968751 (Hg38)
End
133980996/132968751 (Hg38)
Orient
+
Location type
Intronic
Target gene
TG
miRNAs that regulate target gene
hsa-let-7f-5p ; hsa-mir-550b-2-5p ; hsa-mir-7855-5p ; hsa-mir-937-5p ; hsa-mir-4710 ; hsa-mir-4792 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-2467-3p ; hsa-mir-5702 ; hsa-mir-1827 ; hsa-mir-1247-3p ; hsa-mir-4257 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-758-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-3611 ; hsa-mir-383-3p ; hsa-mir-6844 ; hsa-mir-7161-3p ; hsa-mir-3156-5p ; hsa-mir-185-5p
Nearest miRNA
hsa-mir-1204/Upstream/2960298; hsa-mir-10400/Downstream/77730;
Nearest TSS
ENST00000518652/Upstream/4144; ENST00000520089/Downstream/707;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/192961, chr8-CpG: 126/Downstream/327572
Upstream sequence
ccaaatgtgtggtgggaacttgttgactctaggtttctttgagggataatcctgttgggttgccctttggggaattcctcatgccagtatttttaggttc
Downstream sequence
ctccttcagaggagtttctcaacacctggccttggggcacgaacctggctcctggtggtttgggcaccaaataaatctggaaaatgtcggggggacacct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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