Basic Information
VIS ID
TVIS44019953
Fusion event
HTLV-1-SH2D4A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
19199208/19341697 (Hg38)
End
19199208/19341697 (Hg38)
Orient
+
Location type
Intronic
Target gene
SH2D4A
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-8055 ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-4468 ; hsa-mir-873-3p ; hsa-mir-942-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-4469 ; hsa-mir-7113-3p ; hsa-mir-6832-3p ; hsa-mir-4461
Nearest miRNA
hsa-mir-124-1/Upstream/1660040; hsa-mir-10400/Downstream/2903269;
Nearest TSS
ENST00000518652/Upstream/22107; ENST00000518093/Downstream/19091;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/27152, chr8-CpG: 20/Downstream/119822
Upstream sequence
tttgggaggccgaggcagatggatcacttgaagccaggagttcaacaccagtctgggcaacatggcgaaaccctgtctctataaaaaacacaaaaattag
Downstream sequence
tcaggcatggtggcatgcacctgtagtcccagctgcttgggaggctggggtgggagatcactttagctgaggaggcagaagttgcagcgagctatgatca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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