Basic Information
VIS ID
TVIS44019956
Fusion event
HTLV-1-PEBP4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
22586033/22728520 (Hg38)
End
22586033/22728520 (Hg38)
Orient
+
Location type
Intronic
Target gene
PEBP4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-124-1/Upstream/483483; hsa-mir-10400/Downstream/2225276;
Nearest TSS
ENST00000518652/Upstream/35218; ENST00000520914/Downstream/149452;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/24636, chr8-CpG: 114/Downstream/136280
Upstream sequence
ACTGTGGAAGGATAGACCCTTCCCCCACGAGCCCCTTGTACTTTGTCTTCTTCACCTGATACAGGTGAGATAGAtctttccttccttccttcattccttg
Downstream sequence
ctggcttgcttctttcttccttcctttctttctttctttcttccttccttccttccttccttccttccttccttccttccttccttccttccCttttttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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