Basic Information
VIS ID
TVIS44019960
Fusion event
HTLV-1-DOCK5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
25088842/25231326 (Hg38)
End
25088842/25231326 (Hg38)
Orient
+
Location type
Intronic
Target gene
DOCK5
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-21-5p ; hsa-mir-7-5p ; hsa-mir-98-5p ; hsa-mir-16-5p ; hsa-mir-877-3p ; hsa-mir-93-3p ; hsa-mir-222-3p ; hsa-mir-4762-5p ; hsa-mir-4719 ; hsa-mir-513b-3p
Nearest miRNA
hsa-mir-124-1/Upstream/277459; hsa-mir-10400/Downstream/114076;
Nearest TSS
ENST00000518652/Upstream/46461; ENST00000495236/Downstream/65256;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/46021, chr8-CpG: 134/Downstream/226444
Upstream sequence
cattttccctgccatatagaattctatatctgaatatgccataatttatttctccgttttcctttccatggacattaggggtgaatctcttttcaaaggg
Downstream sequence
ctatcacacacagtgcttccgtgaactttcttggacatatttcctggtacacttgtgcaagtgtttctctggggcataGTCTTCAGATTACTACACTTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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