Basic Information
VIS ID
TVIS44019962
Fusion event
HTLV-1-ELP3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
28044997/28187480 (Hg38)
End
28044997/28187480 (Hg38)
Orient
+
Location type
Intronic
Target gene
ELP3
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-342-5p ; hsa-mir-193b-3p ; hsa-mir-3934-3p ; hsa-mir-3664-3p ; hsa-mir-1324 ; hsa-mir-4524b-3p ; hsa-mir-4684-5p ; hsa-mir-3675-3p ; hsa-mir-5583-3p ; hsa-mir-6771-3p ; hsa-mir-548c-3p ; hsa-mir-4786-5p ; hsa-mir-7162-3p ; hsa-mir-544b ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-6765-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-4293
Nearest miRNA
hsa-mir-124-1/Upstream/301364; hsa-mir-10400/Downstream/317636;
Nearest TSS
ENST00000518652/Upstream/28882; ENST00000518479/Downstream/129506;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/94129, chr8-CpG: 160/Downstream/197920
Upstream sequence
ctacagtgaataaaacaaaatccctgccctcctggagccttcattctgttctcaaaacagcagtcagatcatgtccctcctttgaccagcatcctctcat
Downstream sequence
tcttccatctcactcagaataaaagccagattccttaggagacctgcatgatggtgcctccttgttccttgagtaagttgagtgcacgcccgtctcagga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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