Basic Information
VIS ID
TVIS44019971
Fusion event
HTLV-1-UNC5D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
35230670/35373152 (Hg38)
End
35230670/35373152 (Hg38)
Orient
+
Location type
Intronic
Target gene
UNC5D
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-4328 ; hsa-mir-129-5p
Nearest miRNA
hsa-mir-124-1/Upstream/5415804; hsa-mir-10400/Downstream/5897896;
Nearest TSS
ENST00000518652/Upstream/137377; ENST00000474634/Downstream/171240;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/136559, chr8-CpG: 351/Downstream/2321274
Nearest cancer related gene
UNC5D(TSG, No orient, 0)
Upstream sequence
GTGGTCTGCCCCATTCCCATGCATTGGCTAACTTTGATATCCTTTCCTGAAGGGTATCCTTTTCACGTGTACTTCTTCTGTGGCTTCCTATGTAAAAATA
Downstream sequence
AATAGCATCACTAATGCTCAGCCTATCTTGATTCTTTCTGAAGGGTAACAAAGGGCAGTGTTGCATTTCAGAATAGTTTTGCTTTTTTAAACAAATAAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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